Hanna Przepiera-Będzak
Pomeranian Medical University in Szczecin, Poland
Title: Serum markers of endothelial function in constellation with disease activity and lipid profile in spondyloarthritis
Biography
Biography: Hanna Przepiera-Będzak
Abstract
Objectives: To examine serum markers of endothelial function in spondyloarthritis (SpA).
Patients & Methods: We studied 157 SpA patients: 81 with ankylosing spondylitis (AS), 76 with psoriatic arthritis (PsA). We assessed VAS, BASDAI, DAS28, ASDAS-ESR, PASI, serum IL-18, sICAM-1, fetuin-A, ET-1, IL-6, IL-23, VEGF, EGF, CRP, ESR and lipid profile.
Results: Serum IL-18 levels were higher in SpA patients than in controls (P=0.0003). Serum IL-18 positively correlated with CRP (P=0.03), VEGF (0.03) and TC (P=0.006) in AS and with IL-6 (P=0.03) and BASDAI (P=0.03) in PsA. SpA patients, compared to controls, had 3.22 increased risk of increased serum IL-18 (95% CI 1.37–7.55, P=0.007). There were no differences of serum sICAM-1 between SpA patients and controls (P=0.2). Serum sICAM-1 positively correlated with CRP (P=0.01), ESR (P=0.01), and IL-6 (P=0.008) in AS. Serum fetuin-A levels were lower in SpA patients than in controls (P=0.001). Serum fetuin-A negatively correlated with CRP (P=0.04) and positively correlated with TC (P=0.004), LDL-C (P=0.01) and TG (P=0.004) in AS. Serum ET-1 levels were lower in SpA patients than in controls (P=0.03). Serum ET-1 positively correlated with ESR (P=0.04) and DAS28 (P=0.003) in PsA.
Conclusions: We confirmed abnormal endothelial function in SpA and markers of endothelial function correlated with disease activity and TC.